A Study on the Liver Function Indices LU3 and LU15 with 99mTc-GSA.

Correlation of LU3 (LU15) which represents the cumulative uptake of99mTc-GSA from 3 (15) to 4 (16) min after injection and hepatic blood flow or receptor quantity was studied. The subjects consisted of 14 patients, including 13 patients with liver cirrhosis or chronic hepatitis and 1 patient with normal liver. LU3 and L U15 showed a good correlation with the ratio of99mTc-GSA binding to receptor and the total injected99mTc-GSA, estimated by whole body scan. LU3 and LU15 also well correlated with the maximal removal rate by nonlinear compartment model, on the other hand, they showed a poor correlation with the hepatic blood flow. It was concluded that LU3 and LU15 chiefly reflect the amount of receptors in the liver.