The Synthesis and Biological Evaluation of Anithiactin A/Thiasporine C and Analogues
AUSTRALIAN JOURNAL OF CHEMISTRY（2016）
Abstract
The synthesis of anithiactin A has been achieved in four steps. Several closely related analogues were synthesised and their biological activity against colon and breast cancer cell lines evaluated. Anithiactin A was found not to be cytotoxic even at a high concentration (100 mu M); however, two 4-substituted phenyl thiazoles were found to be moderately cytotoxic at 10 mM. Based on these results, 4-substitution on the phenyl group appears to be critical for cytotoxicity. However, the exact electronic and structural requirements are unclear.
MoreTranslated text
Key words
peptide,reaction mechanisms,mass spectrometry,biological chemistry,ab initio calculations,nanotechnology,educational,ionic liquids,colloids,pharmaceutical chemistry,photochemistry,structure,surface chemistry,analytical chemistry,quantum chemistry,green chemistry,polymer chemistry,biosensors,physical chemistry,kinetics,medicinal chemistry,computational chemistry,organic chemistry,crystal structures,density functional theory,spectroscopy,interfaces,electrochemistry,enzymes,sensors,supramolecular chemistry,combinatorial chemistry,inorganic chemistry,amino acids,biocatalysis,combinatorial,crystallography,self assembly,catalysis,macromolecules,proteins
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined