Rationally designed non-enzymatic fluorogenic ‘turn-on’ probe for uric acid
Dyes and Pigments（2015）
Abstract
The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120–380 μM) with ‘turn-on’ fluorogenic behaviour.
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Key words
Uric acid,Fluorescence,BODIPY,Non-enzymatic,PET,Hydrogen bonding
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