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Cu-OMS-2-catalyzed decarboxylation–acetoxylation of (3 R ,4 R )-4-acid-3-[( R )-1-(( t -butyl-dimethylsilyl)oxy)-ethyl]-1-methoxyphenyl-2-azetidinone with NaBrO 3 /NaOAc

Research on Chemical Intermediates(2012)

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摘要
(3 R ,4 R )-4-Acetoxy-3-[( R )-1(( t -butyldimethylsilyl)oxy)-ethyl]-1-methoxyphenyl-2-azetidinone (an important precursor for the synthesis of carbapenem antibiotics) was synthesized under mild and green conditions catalyzed by Cu-OMS-2. Normal to excellent isolated yields were obtained under given conditions.
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关键词
Azetidinone, Decarboxylation, Acetoxylation, Cu-OMS-2
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