A rapid and an efficient synthesis for 3,5-disubstituted 1,2,4-oxadiazoles under microwave irradiation
Research on Chemical Intermediates（2013）
Abstract
The one-pot, three-component reaction of aromatic nitriles, hydroxylamine hydrochloride, and sodium carbonate in ethylene glycol provided 3,5-disubstituted 1,2,4-oxadiazoles. These 1,2,4-oxadiazole derivatives are quickly prepared under microwave irradiation (2 h) in high yields and excellent state of purity. The synthesized compounds were characterized by means of their 1 H, 13 C NMR, mass spectroscopy data and elemental analysis.
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Key words
1,2,4-Oxadiazole,Nitrile,Microwave,NMR
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