Knockdown of central ghrelin O-acyltransferase by vivo-morpholino reduces body mass of rats fed a high-fat diet

•Ghrelin-O-acyltransferase (GOAT) mRNA expression is present in the hypothalamus of rats.•Hypothalamic GOAT mRNA expression changes in response to changes in energy state.•Knockdown of hypothalamic GOAT expression via chronic intracerebroventricular infusions of a GOAT antisense-morpholino decreases and weight gain in rats fed a high fat diet.