Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists

Brian C Shook, Devraj Charavarty,J Kent Barbay,Aihua Wang,Kristi Anne Leonard,Vernon C Alford,Mark T Powell,Derek A Beauchamp,Stefanie Rassnick,Robert H Scannevin,Karen Carroll,Nathaniel H Wallace,Jeffrey J Crooke,Mark Ault,Lisa Lampron,Lori Westover,Kenneth Rhodes,Paul F Jackson

MedChemComm（2011）

引用 13|浏览37

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摘要

A novel series of aminomethyl substituted thieno[2,3-d]pyrimidines have been identified as adenosine A(2A) receptor antagonists. Analogues show excellent in vitro activities and have excellent activity in vivo in mouse models of Parkinson's disease.

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关键词

Adenosine Receptors

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