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Discovery of novel selective Sigma-1 ligands as cognitive enhancers

Anne Valade,Sophie Binet Cross,Claire Brown,Eric Detrait,Doina Ene,Michel Gillard,Michel Guyaux,Yves Lamberty, M A Maguire,Nivedita Namdev,Laurent Provins,Eric Schwartz,Celine Vermeiren

MEDCHEMCOMM（2011）

Cited 6|Views11
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Abstract
We disclose the identification and SAR of phenylcyclopropylcarboxamide compounds as novel, selective Sigma-1 ligands presenting excellent drug-like properties, high solubility and metabolic stability. A selected representative, compound 14, demonstrated in vivo very good brain exposure and antiamnesic effect in a mouse model of recognition memory.
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