JC virus-iLOV fluorescent strains enable the detection of early and late viral protein expression
Journal of Virological Methods(2015)
Abstract
•We created two fluorescent gene iLOV-labeled replication-competent JCV constructs. which can generate visible green fluorescence signal in infected cells.•These constructs can be used to directly monitor JCV replication in vitro.•This monitoring method will greatly facilitate the screening of anti-JCV therapies.
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Key words
JC virus,iLOV,Drug screening,Therapy,PML
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