Top-down characterization of biopharmaceuticals
TrAC Trends in Analytical Chemistry（2013）
Abstract
Applied mass spectrometric techniques can fundamentally be divided into those starting from intact proteins (top down) and those starting from peptides derived by chemical or, more commonly, enzymatic digestion (bottom up). This article primarily covers top-down analysis and the information that it can obtain. It therefore covers electrospray ionization and matrix-assisted laser desorption/ionization techniques and top-down fragmentation techniques. (C) 2013 Elsevier Ltd. All rights reserved.
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Key words
Biopharmaceutical,Biosimilar,Deamidation,Fragmentation,Glycoprotein,Glycosylation,Ionization,Mass spectrometry (MS),Protein characterization,Top-down analysis
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