142 Diagnostic Yield and Safety of EUS-Guided Single-Incision Needle-knife (SINK) Biopsy for Cyto-Histological Tissue Diagnosis in Upper Gastrointestinal Subepithelial Lesions

Subepithelial tumors (SETs) frequently lack distinct EUS features, so final diagnosis demands adequate methods of acquisition of tissue. However, histologic disgnosis of SETs is challenging: EUS-guided FNA is limited by low yield for samller lesions and often fails to provide sufficient tissue for immunohistochemistry (IH). EUS-guided SINK biopsy is a novel method for tissue sampling with promising preliminary results in a previous pilot study (De la Serna et al, GIE 74(3)2011)