198 PDX-1 mRNA Expression in Endoscopic Ultrasound-Guided Fine Needle Cytoaspirate As a New Marker for the Diagnosis of Pancreatic Cancer

Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) is considered a major advance for the diagnosis of pancreatic lesions, given its ability to obtain cytologic material. The sensitivity of the cytologic study is modest, with limits also represented by sampling adequacy. Efforts to define new tests to improve the efficacy of EUS-FNS are needed. PDX-1 is a transcription factor required for pancreatic development. Studies have shown that PDX-1 is expressed in cases of pancreatic adenocarcinoma, and its expression correlates with a worse prognosis.