Thematic stream: co-morbidity (PP59–PP86) PP59. A Single Dose of Indomethacin does not Prolong Premotor Reaction Time in Young Healthy Adults: A Randomised, Placebo Controlled, Double-Blind, Cross-Over Study

Background: Indomethacin, commonly used in rheumatology practice, crosses blood brain barrier and has many effects on the central nervous system, some are undesirable and others are advantageous especially in patients with cognitive dysfunction. We aimed to test the hypothesis that a single dose of indomethacin would affect information processing speed in healthy subjects. Methods: Thirty healthy adult volunteers were enrolled in the study. Single dose of 25 mg indomethacin or placebo were administered to blinded healthy adults in a random, cross-over design. Premotor reaction and response times were measured electromyographically before and after the administration of preparations by a blinded researcher. Results: There was no statistically significant difference in mean values of premotor and response time measurements after indomethacin or placebo compared to baseline values. Mean difference values of premotor time measurements did not differ between indomethacin (-8.87 msec) and placebo (2.77 msec) groups (p = 0.073). Mean difference values of response time measurements for indomethacin and placebo groups were 14.23 and 15.30 msec, respectively (p = 0.946). Conclusions: A single dose of indomethacin did not change premotor reaction time and response time in healthy adults. It does not seem to deteriorate information processing speed in healthy adults.