3.23 Targeted Nanoparticle Delivery Overcomes Off-Target Immunostimulatory Effects of Oligonucleotides and Improves Therapeutic Efficacy

Targeted Nanoparticle Delivery Overcomes OffTarget Immunostimulatory Effects of Oligonucleotides and Improves Therapeutic Efficacy Natarajan Muthusamy, Bo Yu, Yicheng Mao, LiYuan Bai, Sarah EM Herman, Asha Ramanunni, Xiaokui Mo, Yan Jin, Cheney Carolyn, Kenneth K. Chan, David Jarjoura, Guido Marcucci, Robert J. Lee, John C. Byrd, L. James Lee Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH; Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH; NSF Nanoscale Science and Engineering Center (NSEC), The Ohio State University, Columbus, OH; Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Center for Biostatistics; The Ohio State University, Columbus, OH