Long Term And Stable Supply Of Reconstituted Neutrophils Achieved By Reduced Intensity Conditioning With Allo-Bmt Induced Remission Of Infammatory Status In X-Cgd Without Procedure Related Complication

X-linked chronic granulomatous disease (X-CGD) is a primary immunodeficiency of phagocytes, resulting in recurrent infection and in development of granuloma formation by chronic inflammation. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the curable procedures. However, this approach has been reluctantly offered because of 1) procedure related toxicity, 2) graft failure, and 3) graft-versus-host disease (GVHD). We have established the reduced intenstity conditioning with allogeneic bone marrow transplantation (allo-BMT) for achievement of durable mixed chimerism without GVHD. This less toxic regimen was attempted to mouse model of human X-CGD for cure without complications.