6-Endo Heck Cyclization of 3-(2-Iodophenoxy)methylbenzofurans: A Useful Approach to Pterocarpenes

Katherine J Fowler,Jillian L Ellis,Gary W Morrow

SYNTHETIC COMMUNICATIONS（2013）

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摘要

Mitsunobu coupling of 3-hydroxymethylbenzofurans with o-iodophenols affords 3-(2-iodophenoxy)methylbenzofurans which under go a useful 6-endo Heck cyclization under Jeffery conditions to afford pterocarpene-type heterocycles. The unsubstituted parent pterocarpene thus prepared was readily converted to coumestan via subsequent PCC oxidation.

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关键词

Coumestan,6-endo cyclization,Heck reaction,3-hydroxymethylbenzofuran,isoflavonoid,Mitsunobu reaction,o-iodophenol,pterocarpene

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