Immunogenicity and efficacy in mice of an adenovirus-based bicistronic rotavirus vaccine expressing NSP4 and VP7

Li Xie,Min Yan,Xiaonan Wang,Jing Ye,Kai Mi,Shanshan Yan,Xianglian Niu,Hongjun Li,Maosheng Sun

Virus Research（2015）

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摘要

•We constructed a recombinant adenovirus expressing NSP4 and VP7 of rotavirus.•The immunogenicity and efficacy of the recombinant adenoviruses was evaluated.•The bicistronic vaccine elicited systematic immunity and provided protection from RV shedding.•Co-expression strategy is valuable for rotavirus vaccine development.

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关键词

Rotavirus,NSP4,VP7,Recombinant adenovirus,Vaccine,Immunogenicity,Bicistronic

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