Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice

Lisheng Yang,Shuxuan Li,Yajing Liu,Wangheng Hou,Qiaona Lin,Huan Zhao,Longfa Xu,Delei He,Xiangzhong Ye,Hua Zhu,Tong Cheng,Ningshao Xia

Virus Research（2015）

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摘要

•Construction and characterization of an infectious clone of coxsackievirus A6.•The whole genome sequence of CA6 strain 141 was determined.•Two kinds of viral particles were observed under transmission electron microscopy.•The CA6 strain 141 showed high virulence in one-day-old BALB/c mice.

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HFMD,FITC,ORF,RD,TCID50,TEM,UTR

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