Molecular characterization of Enterobacteriaceae resistant to carbapenem antimicrobials

Jaciane Baggiotto Marques,Pauline Cordenonsi Bonez,Vanessa Albertina Agertt,Vanessa C Flores,Tanise Vendruscolo Dalmolin,Grazielle Guidolin Rossi,Nara Lucia F Dal Forno, Bianca Bianchini,Caren Rigon Mizdal,Fallon Siqueira,Roselene Alves Righi,Bettina Meneghetti,Priscila Trindade,Roberto Christ Vianna Santos,Marli M A Campos

Jornal Brasileiro De Patologia E Medicina Laboratorial（2015）

Cited 6|Views41

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Abstract

The present study aimed to genotypically and phenotypically characterize clinical isolates of carbapenem-resistant Enterobacteriaceae collected from inpatients at the University Hospital of Santa Maria, during seven months. Among the clinical isolates subjected to the modified Hodge test (MHT), 62.5% were positive, indicating possible production of carbapenemase. Polymerase chain reaction (PCR) demonstrated that blaKPC was the most frequently found gene (31%), followed by blaIMP (12.5%). Combined use of the methods is needed to identify carbapenem resistance in enterobacteria to prevent their spread and control the infections caused by these organisms.

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Key words

enterobactérias,carbapenemases,métodos fenotípicos,métodos moleculares

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