A facile strategy to prevent trifluoroacetylation of N-terminal proline peptides
Tetrahedron Letters(2012)
摘要
Unwanted trifluoroacetylation occurred at the N-terminus of prolinyl peptides during detachment from the solid phase. This was observed when the N-α-Fmoc protecting group had been removed prior to the final TFA treatment. Subtly changing the SPPS protocol and incorporating Boc- in place of the Fmoc-protected proline as the N-terminal building block efficiently suppressed this side reaction.
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关键词
Solid-phase peptide synthesis,N-terminal proline,Modification,Trifluoroacetylation
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