LiOO t -Bu as a terminal oxidant in a titanium alkoxide-mediated [2+2+2] reaction cascade
TETRAHEDRON LETTERS(2015)
摘要
LiOOt-Bu is an effective oxidant for converting the penultimate organometallic intermediate generated in a titanium alkoxide-mediated [2+2+2] reaction cascade to an allylic alcohol. Oxidation of the presumed allylic titanium species is highly regioselective, providing direct access to substituted hydrindanes containing a primary allylic alcohol. In addition to demonstrating the feasibility of this oxidation process, we document the ability to convert the primary allylic alcohol products to angularly substituted cis-fused hydrindanes. (C) 2015 Elsevier Ltd. All rights reserved.
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关键词
Metallacycle-mediated cross-coupling,Cascade reaction,Oxidation,Hydrindanes,[2+2+2]
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