A facile synthesis of 3-trifluoromethyl-1,2,4-oxadiazoles from cyanamides
Tetrahedron Letters（2014）
摘要
A safe and facile method for the formation of 3-trifluoromethyl-5-amino-1,2,4-oxadiazoles, via a reversed addition of hydroxylamine to cyanamides, is reported. This two-pot procedure is suitable to scale-up and avoids the hazards associated with trifluoromethyl amidoxime synthesis.
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关键词
3-Trifluoromethyl-1,2,4-oxadiazoles,Cyanamides,N-Boc-hydroxylamine,1,2,4-Oxadiazoles
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