Microwave-assisted Claisen rearrangement of naphthyl 2-propynyl ethers: synthesis of naphthofurans
Tetrahedron Letters(2012)
摘要
An efficient two-step approach for the synthesis of naphtho[1,2-b]furans and naphtho[2,1-b]furans has been developed. Various functionalized propargyl alcohols were etherified with α- or β-naphthol under Mitsunobu reaction conditions to give naphthyl 2-propynyl ethers, which underwent a facile microwave-assisted Claisen rearrangement and concomitant anionic cyclization to yield naphthofuran derivatives under basic reaction conditions.
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关键词
Naphtho[1,2-b]furans,Naphtho[2,1-b]furans,Naphthyl 2-propynyl ethers,Claisen rearrangement,Cesium fluoride,Mitsunobu reaction,Microwave irradiation
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