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Catalyst-free, ethylene glycol promoted one-pot three component synthesis of 3-amino alkylated indoles via Mannich-type reaction

U Chinna Rajesh,Rohit Kholiya,V Satya Pavan,Diwan S Rawat

Tetrahedron Letters（2014）

Cited 34|Views4
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Abstract
•Catalyst free conditions for the synthesis of 3-amino alkylated indoles.•This method is useful for large scale production of 3-amino alkylated indoles.•Avoids the use of column chromatography for the purification of final products.•Ethylene glycol is as a green promoted medium.
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Key words
Multi-component reactions,E-factor and atom economy,Indoles,Mannich reaction,Catalyst free
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