Antinociceptive effect of intrathecal amiloride on neuropathic pain in rats.

Peizong Wang,Handong Ouyang,Qiang Li,Lei Hao,Yang Huang,Weian Zeng

Neuroscience Letters（2015）

Cited 8|Views4

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Abstract

•Intrathecal amiloride can produce the antinociception on neuropathic pain.•The antinociception is dose- and time-dependent.•Amiloride inhibits c-Fos and p-p38 MAPK in the spinal dorsal horn.•The effect of amiloride is through inhibiting neurons and microglia activation.

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Key words

Neuropathic pain,Amiloride,c-Fos,p38 MAPK

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