Segmental resection and recosntruction of main peripancreatic vessels during laparoscopic robot assisted pancreatectomy

s / Pancreatology 12 (2012) 502–597 547 Methods: COUP-TFII expression in pancreatic tumor samples was evaluated by immunohistochemistry. Pancreatic cancer cell lines expressing inducible shRNA against COUP-TFII were produced and injected in nude mice. Results: COUP-TFII is expressed in primary samples and correlates with overall survival. Silencing of COUP-TFII reduces the proliferation, migration, anchorage independent growth and it strongly inhibits tubule formation, whereas in nude mice the silencing reduces tumor growth by 50%. Conclusions: COUP-TFII influences the behavior of pancreatic adenocarcinoma, thus representing a new target for pancreatic cancer therapy.