Protective Effects of 5,7,3’,4’-Tetramethoxyflavone on Proliferation of Rat Chondrocytes Induced by IL-1β
Advanced Materials Research(2014)
Abstract
Osteoarthritis (OA) is a degenerative joint disease that affects millions of people. Currently, there is no effective drug treatment for it. The purpose of this study is to investigate the chondroprotective effects of 5,7,3’,4’- tetramethoxyflavone in isolated cartilage chondrocytes cultured pre-treatment by IL-1β. The results showed that 5,7,3’,4’- tetramethoxyflavone could significantly down regulate the concentration of MMP-13, but up regulate the expression of TIMP-1, increase the proliferative activity of rat chondrocytes.
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