Inhibiting Effects of Taurine on Doxorubicin-Induced Oxidative Stress in Rats

The study was designed to observethe protective effect of taurine(Tau) against doxorubicin-induced cardiotoxicity in rats.Doxorubicin were administered at the dosage of 2.5 mg·kg-1 oncea week, ip for a period of 4 consecutive weeks. Taurine were administered atthe dosages of400,200and 100 mg·kg-1·d-1, poby gavage for 30 consecutive days. Taurine at the doses of 400 and 200 mg·kg-1significantly reduced CK-MB, GOT and LDH and increased SOD levelsin the doxorubicin-treated animals. Thus, taurine ameliorated doxorubicin-induced cardiotoxicity by reducingoxidative stress, abnormal cellular morphology in rat. The study show the protective effect oftaurine against doxorubicin-induced cardiotoxicity.