Retarding Bioactivity Effect of Ciprofloxacin Incorporated in Polyvinyl Alcohol/Bioglass Scaffold as Bone Graft

The biomaterials are used for many biomedical applications. The main objective of the present work was to investigate the potential role of Bioglass (Melting)- Polyvinyl alcohol (BG (M)-PVA) and Bioglass (Melting)-Polyvinyl alcohol-20%Ciprofloxacin (BG (M)-PVA-20Cip) in regenerative bone capacity. These composites were implanted in the femoral condyles of Wistar rats and compared to that of ovariectomised groups. Our results noted, after the different period of implantation (15, 30, 60 and 90 days), that the Alkaline phosphatase (ALP) and Acid phosphatase (ACP) activities showed an excellent osteoinductive property of BG (M)-PVA, that this phenomena decreased with the presence of ciprofloxacin. Physico-chemical techniques (ICP-OES and SEM) were engaged to highlight the influence of antibiotic on the structure, porosity and bioactivity of a porous Glass-PVA before and after implantation. The results obtained by ICP-OES showed a rapid reduction in silicon (Si) and sodium (Na), and noted an accelerator increase in calcium (Ca) and phosphorus (P) ion concentrations in BG (M)-PVA that the BG (M)-PVA-20Cip. This result is confirmed by SEM. We can conclude that the loading of ciprofloxacin in BG (M)-PVA is characterized by a retard effect of formation of apatitic phase.