Recombinant invasive Lactococcus lactis can transfer DNA vaccines either directly to dendritic cells or across an epithelial cell monolayer

Marcela De Azevedo,Marjolein Meijerink,Nico Taverne,Vanessa Bastos Pereira,Jean Guy Leblanc,Vasco Azevedo,Anderson Miyoshi,Philippe Langella,Jerry M Wells,Jeanmarc Chatel

Vaccine（2015）

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摘要

•Validation of Lactococcus lactis as a DNA delivery vehicle for major antigen-presenting cell, dendritic cells.•Recombinant L. lactis expressing Listeria monocytogenes mutated internalin A (mInlA) is a better vector than wild type strain.

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关键词

Lactococcus lactis,Mutated internalin A,Listeria monocytogenes,Internalization,Dendritic cells,DNA delivery,β-lactoglobulin

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