Mild cognitive impairment subjects with neuroimaging markers of Alzheimer's disease and cerebrovascular disease are more cognitively impaired than mild cognitive impairment subjects with Alzheimer's disease alone
Alzheimers & Dementia(2012)
Abstract
demonstrably strong loadings on d. All observed variables were adjusted for age, gender and education. Conclusions: A latent variable approach to dementia case finding can result in highly accurate dementia endophenotypes. In this case, d has been constructed entirely from verbal measures which could be administered over the telephone in less than 30 minutes. Because a latent construct is “error-free,” we were able to accurately predict the diagnoses of blind clinicians using a verbal battery in a minority sample with demonstrably low educational attainment and variable acculturation. Moreover, the resulting latent construct can be output as a continuous variable, representing dementia’s endophenotype in Hispanics. This can be interrogated for its serum and genetic biomarkers.
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Key words
mild cognitive impairment subjects,alzheimer disease,cognitive impairment,cerebrovascular disease
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