Mild cognitive impairment subjects with neuroimaging markers of Alzheimer's disease and cerebrovascular disease are more cognitively impaired than mild cognitive impairment subjects with Alzheimer's disease alone

demonstrably strong loadings on d. All observed variables were adjusted for age, gender and education. Conclusions: A latent variable approach to dementia case finding can result in highly accurate dementia endophenotypes. In this case, d has been constructed entirely from verbal measures which could be administered over the telephone in less than 30 minutes. Because a latent construct is “error-free,” we were able to accurately predict the diagnoses of blind clinicians using a verbal battery in a minority sample with demonstrably low educational attainment and variable acculturation. Moreover, the resulting latent construct can be output as a continuous variable, representing dementia’s endophenotype in Hispanics. This can be interrogated for its serum and genetic biomarkers.