CSF β-AMYLOID AND PHOSHO-TAU INTERACTIONS ON BRAIN STRUCTURE IN PRECLINICAL AD

clinical characteristics of probable CAA based on Boston’s criteria and also investigated predictive factors associated with certain features of CAA. Methods: We retrospectively reviewed patients diagnosed as probable CAA based on the Boston’s criteria who underwent MRI, including gradient echo (GRE) andfluid attenuated inversion recovery (FLAIR) images and clinical assessment fromAugust 2006 toMay 2013.AllGRE images of each subject were reviewed by 1 rater to describe the location and numbers of intracranial hemorrhages. The white matter hyperintensity was rated based on rating scales proposed by Clinical Research Center for Dementia of South Korea (CREDOS). Statistical analyses were performed using SPSS version 21.0 and SAS 6.0.Results: A total of 92 patients were included in this study. Themean age of onsetwas 68.669.9years (M:F1⁄461:31). Sixty-three patients (68%) had hypertension. The initial diagnoses included cognitive impairment (48 patients, 52%), lobar ICH (14 patients, 15.2%), and lacunar infarction (10 patients, 10.9%). Thirty-nine patients had deep microbleeds. Fifty-three patients (57%) showed posterior dominant distribution (parietal and occipital lobe) of hemorrhages. Themedian number of microbleeds was 15 [interquartile range (IQR): 7-41.33]. Patients with posterior dominant location were older (p 1⁄40.028) and complained of cognitive decline more often (p 1⁄40.034). This group had more microbleeds (p1⁄40.006) and showed more severewhitematter hyperintensities (p1⁄40.008). They also tended to have lower recall score of MMSE than the other group. Patients with deep microbleeds showed more severe white matter hyperintensities (p 1⁄40.002). Twenty-four patients performed follow-up MR imaging. The mean interval time was 28.6624.2 months. Large number of microbleeds at baseline was associated with increasing rate of newmicrobleeds at follow-up scan.Conclusions:We found the impact of location of intracranial hemorrhages on cognitive impairment andwhitematter hyperintensities in patientswithCAA.Thedistribution and the number of microbleeds at baseline were factors associated with disease progression. These data indicate that early evaluation of the location and number of microbleeds can be helpful to assess clinical characteristics and prognosis in patients with probable CAA.