Cortical thickness and subcortical volumes in mild cognitive impairment patients showing different biomarker profiles

Mild cognitive impairment (MCI) patients with different biomarker profiles might be characterized by different patterns of cortical thinning and subcortical atrophy. 53 MCI patients (mean age 71, female 49%) were enrolled from 2 Italian Memory Clinics. Abeta42 and Tau CSF levels, temporo parietal hypometabolism and hippocampal volumes were measured. According to their biormarker profiles, patients were divided in two groups: (i) suspected n on-amyloid pathology (SNAP, N=21) and (ii) patients with amyloid plus neurodegeneration (A+N, N=32). Cortical thickness and sucortical volumes were quantified using the freesurfer pipeline. Comparisons were made at group level with 15 subjective memory complainers (SMC), considered as the control group. SMC were cognitively intact, younger than SNAP and A+N patients (p