HYDROGEN BOND INTERACTIONS AND THEIR INFLUENCE ON CONFORMATION OF RETINOIDAL-ACTIVE AND INACTIVE AROMATIC ANILIDES

Tolterodine is a drug substance contammg (+)-N,Ndiisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylprolylamine hydrogen L(+)-tartrate CC26H37N07).The drug is used for the treatment of minary frequency, urgency and/or urge incontinence.The synthesis of tolterodin L( +)-tartrate is a well established procedure.The crystal structure of tolterodine L( +)-tartrate was determined from single crystal x-ray data at room temperature and 30 K. The structure is monoclinic with two formula units in.the unit cell and all the atoms in the general position of the space-group P2J.The unit cell dimensions at 30 K are a= 9.1759, b = 16.3965c=l2.9196A.= 93.427".In the final stage of the refinement the 3568 reflections recorded at 30 K were refined to an R-value of 4.0%.