(Solid+liquid) phase diagram for (indomethacin+nicotinamide)-methanol or methanol/ethyl acetate mixture and solubility behavior of 1:1 (indomethacin+nicotinamide) co-crystal at T = (298.15 and 313.15)K

The Journal of Chemical Thermodynamics(2015)

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摘要
•Ternary phase diagrams of (IMC+NCT)-methanol or methanol/ethyl acetate mixture at T=(298.15 and 313.15)K were measured.•The effects of temperature and introduced ethyl acetate on solid phase stability were discussed.•Solubility of (IMC+NCT) cocrystals was first correlated using a model considering solubility product and complexation.•Solubility of (IMC+NCT) cocrystals as a function of co-former concentration was evaluated.
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关键词
Indomethacin,Co-crystal,Solvate,Solubility,Phase diagram
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