Virus replication kinetics and pathogenesis of infection with H7N9 influenza virus in isogenic guinea pigs upon intratracheal inoculation

Lidewij C M Wiersma,Joost H C M Kreijtz,Stella E Vogelzangvan Trierum,Geert Van Amerongen,Peter Van Run,Mechtild Ladwig,Stefanie Banneke,Hubert Schaefer,Ron A M Fouchier,Thijs Kuiken,Albert D M E Osterhaus,Guus F Rimmelzwaan

Vaccine（2015）

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摘要

•Guinea pigs are susceptible to unadapted human and avian influenza viruses.•Influenza A/H7N9 virus is an avian virus first isolated from humans in 2013.•A/H7N9 virus replicated to high titers in the entire respiratory tract of guinea pigs.•Infection caused rhinitis, tracheitis and bronchointerstitial pneumonia.•Peak of viral excretion was at day 2 and continued until 7 days post-inoculation.

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关键词

H7N9,Isogenic guinea pig,Pathogenesis,Animal model,Influenza

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