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Alterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever

Brian B Gowen,Eric J Sefing,Jonna B Westover,Donald F Smee,Joseph Hagloch,Yousuke Furuta,Jeffery O Hall

Antiviral Research（2015）

Cited 38|Views15
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Abstract
•Arenavirus infection altered favipiravir plasma and tissue concentrations and kinetics in hamsters.•Favipiravir conversion to inactive M1 metabolite increased in infected animals.•Reduced plasma favipiravir concentrations correlated with increasing disease severity.
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Key words
Favipiravir,T-705,Arenavirus,Pharmacokinetics,Infection
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