Interleukin-24 inhibits influenza A virus replication in vitro through induction of toll-like receptor 3 dependent apoptosis

Rene Weiss,Johannes Laengle,Monika Sachet,Annapolina Shurygina,Oleg Kiselev,Andrej Egorov,Michael Bergmann

Antiviral Research（2015）

引用 21|浏览28

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摘要

•IL-24 reveals an anti-viral effect against influenza A virus infected cells.•The anti-viral effect of IL-24 involves TLR3 mediated apoptosis.•Mcl-1 is a key regulator in the anti-viral process of IL-24.•IL-24 expressed by an influenza A virus vector exhibits no toxicity in vivo.

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关键词

Influenza A virus,Interleukin-24,Toll-like receptor 3,Apoptosis,Caspase-3,Myeloid cell leukemia 1

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