Abstract 3061: Micro-RNA signature differences in lung cancer patients with ALK translocation, EGFR mutations and KRAS mutations.

Background: Oncogenic driving mutations identify lung adenocarcinoma with different prognosis and sensitivity to targeted therapies. miRNAs are a new class of non-coding RNA involved in gene expression regulation and recent studies have suggested that miRNAs could be useful for stratifying lung cancer subtypes. How miRNAs are dysregulated in lung cancer patients with ALK translocation, EGFR or KRAS mutation is unknown. Aim of the present study is to identify miRNA signature differences according to the presence of specific oncogenic driver and correlation between miRNAs deregulation and drug response.Materials and methods: The study was conducted in a cohort of 70 lung cancer patients including 68 primary cancer tissue (17 ALK positive tumors, 11 ALK negative EGFR positive tumors, 15 ALK negative KRAS positive tumors, 24 ALK negative EGFR and KRAS negative tumors defined as wild-type …