Abstract 2544: Associations between RET/PTC rearrangements, BRAF and RAS mutations and radiation dose, age at exposure, and latency in post-Chernobyl thyroid cancer:

Introduction: Childhood exposure to I-131 from the Chernobyl accident was associated with a dramatic increase in incidence of papillary thyroid cancer (PTC). PTCs are characterized by several genetic alterations including RET/PTC rearrangements and point mutations of BRAF and RAS. Association between mutations and radiation doses has not been studied in post-Chernobyl tumors. Design: We analyzed 70 PTCs diagnosed in a Ukrainian-American cohort who were Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2544. doi:1538-7445.AM2012-2544