P-014 Clonal evolution or expansion occurs frequently in SRSF2-mutated patients with de novo myelodysplastic syndromes progressing to secondary acute myeloid leukemia

Leukemia Research(2013)

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Abstract
The increased greenhouse gas concentration in the atmosphere causes climate change. China and India are among the most significant contributors to global greenhouse gas emissions. The current study forecasts the emissions from the countries' four sectors – Transportation, Building, Waste, and Manufacturing/Construction. By extending the classical discrete grey forecasting model DGM (1, 1), a new data-driven time-series forecasting technique, called DGM (1, 1, α), is proposed and applied to forecast the emissions in these sectors till 2028 with an accuracy of over 95%. The results show that the emissions are generally increasing. However, China continues to show a decline in the emissions from the manufacturing and construction industries. Also, the Posterior-Variance Test is introduced to test whether a given forecasting model is qualified or unqualified for a given problem. The comparative analyses with three forecasting models – DGM (1,1), Even GM (1,1), and Grey Verhulst models –revealed the proposed model's feasibility, flexibility, and accuracy. The study concludes with important recommendations for the policy-makers to develop better emission mitigation policies.
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Key words
de novo myelodysplastic syndromes,secondary acute myeloid leukemia
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