Sex differences in myelin-associated protein levels within and density of projections between the orbital frontal cortex and dorsal striatum of adult rats: Implications for inhibitory control

Neuroscience(2015)

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摘要
•Female rats have previously been reported to display enhanced inhibitory control as compared to males.•Projections from the prefrontal cortex to dorsal striatum (dSTR) play a key role in inhibitory control.•We report that myelin-associated protein levels in the orbital frontal cortex (OFC) are higher in female rats than in males.•Additionally, we report that the density of an OFC-infused anterograde tracer is greater in the dSTR of females than males.•These results suggest a neuroanatomical mechanism that could underlie the enhanced impulse control of female rats.
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ABC,ADHD,ANOVA,BDA,dlSTR,dmSTR,dSTR,EDTA,EGTA,MBP,OFC,PBS,PFC,PLP,TTBS,vSTR
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