1094PDA PHASE 1, DOSE ESCALATION STUDY OF PACLITAXEL WITH GSK1120212 (TRAMETINIB) FOR THE TREATMENT OF ADVANCED MELANOMA

N. Coupe1, P. Corrie2, M. Hategan2, J. Larkin3, M.E. Gore3, A. Gupta1, A. Wise4, S. Suter1, C. Ciria5, S. Love5, L. Collins4, M.R. Middleton1 Medical Oncology, The Oxford Cancer Centre, Churchill Hospital, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Medicine, Royal Marsden Hospital NHS Foundation Trust, London, UK Department of Oncology, University of Oxford, Oncology Clinical Trials Office, Oxford, UK Centre for Statistics In Medicine, University of Oxford, Oxford Clinical Trials Research Unit, Oxford, UK