152P * TRANSARTERIAL CHEMOEMBOLISATION USING DRUG-ELUTING MICROSPHERES DEM-TACE IN LUNG CARCINOMA METASTASES TO THE LIVER IN HUMANS

Aim: The aim of this study was to evaluate the effectiveness and side effects of selective, local injection of microparticles soaked with chemotherapeutic drug into the tumour arteries with simultaneous closure of these vessels in liver metastases in humans with lung carcinoma - DEM-TACE.Methods: We analyzed 7 subjents (4 male, 3 female), aged 52-67 yrs, diagnosed with lung carcinoma in stage IV with liver metastases. All patients had an ECOG performance status score of 2 or less. All of them uderwent the proper chemotherapy depending on histopathological type of the tumor: small cell lung carcinoma or non small cell carcinoma. Transarterial chemoembolisation of metastatic lesions in the liver was conducted using Hepasphere soaked with irinotecan. Follow-up assessment was performed by MRI and CT scans, according to RECIST criteria. All study patients were assessed for 3 weeks after each chemoembolisation. All subjects were monitored for survival for 6, 9 and 12 months. Additionally, we used the quality of life questionnaire - ESAS score before and after each episode of chemoembolisation.Results: In 5 patients out of 7 post-embolic syndrome occurred. Only 1 patient died because of neutropenic fever, after the first episode of chemoembolisation. In 6 study cases a significant improvement of quality of life, according to the ESAS questionnaire, was observed. The positive effect of treatment was documented by CT-scans and MRI in 5 patients. Overall survival was 12 months for 4 patients.Conclusions: Chemoeobolisation using drug-eluting microspheres (DEM-TACE) should be considered in selected group of patients diagnosed with lung carcinoma with liver metastases. It may be a useful method of palliative treatment in some patients in stage IV of this disease.Disclosure: All authors have declared no conflicts of interest. Aim: The aim of this study was to evaluate the effectiveness and side effects of selective, local injection of microparticles soaked with chemotherapeutic drug into the tumour arteries with simultaneous closure of these vessels in liver metastases in humans with lung carcinoma - DEM-TACE. Methods: We analyzed 7 subjents (4 male, 3 female), aged 52-67 yrs, diagnosed with lung carcinoma in stage IV with liver metastases. All patients had an ECOG performance status score of 2 or less. All of them uderwent the proper chemotherapy depending on histopathological type of the tumor: small cell lung carcinoma or non small cell carcinoma. Transarterial chemoembolisation of metastatic lesions in the liver was conducted using Hepasphere soaked with irinotecan. Follow-up assessment was performed by MRI and CT scans, according to RECIST criteria. All study patients were assessed for 3 weeks after each chemoembolisation. All subjects were monitored for survival for 6, 9 and 12 months. Additionally, we used the quality of life questionnaire - ESAS score before and after each episode of chemoembolisation. Results: In 5 patients out of 7 post-embolic syndrome occurred. Only 1 patient died because of neutropenic fever, after the first episode of chemoembolisation. In 6 study cases a significant improvement of quality of life, according to the ESAS questionnaire, was observed. The positive effect of treatment was documented by CT-scans and MRI in 5 patients. Overall survival was 12 months for 4 patients. Conclusions: Chemoeobolisation using drug-eluting microspheres (DEM-TACE) should be considered in selected group of patients diagnosed with lung carcinoma with liver metastases. It may be a useful method of palliative treatment in some patients in stage IV of this disease. Disclosure: All authors have declared no conflicts of interest.