1059 DIETARY INFLUENCE ON SALT-SENSITIVE BLOOD PRESSURE RISE WITH INCREASED HEART RATE

Aim: WHO-coordinated CARDIAC (Cardiovascular Diseases and Alimentary Comparison) Study previously reported individuals excreting Na ≥ the mean of 24 hour urinary (24U) Na of CARDIAC population (CP) and with higher heart rate (HR) ≥ mean HR had significantly higher systolic and diastolic blood pressure (SBP, DBP) than those excreting Na ≥ mean but with HR < mean, indicating possible involvement of impaired reflex suppression of HR by Na induced volume expansion in salt-sensitivity in hypertension. We further investigated the affect of Mg (M) and taurine (T) intakes on salt-sensitive BP rise with increased HR. Methods: From 61 CP in 25 countries, Japanese populations with obviously higher 24UT because of their fish eating custom, and other populations in which M and T were not available, were excluded and 41 CP were used for the following analysis. Results: Among total CP individuals, 708 with 24U Na ≥ mean and HR mean had significantly higher SBP (127.8 ± 0.8) and DBP (78.6 ± 0.8) than SBP (123.6 ± 0.6) and DBP (75.0 ± 0.9) in 1047 with 24 Na ≥ mean and HR < mean. Among 708 males and females with 24UNa and HR ≥ mean, 402 lower M excreters (24UM < mean) showed significantly higher DBP (79.7 ± 0.6) than DBP (76.9 ± 1.0) in 306 higher M excreters (24UM ≥ mean). Among 387 males with 24U Na and HR ≥ mean, 265 lower T excreters (24UT < mean) showed significantly higher SBP (130.0 ± 1.3) and DBP (80.5 ± 0.8) than SBP (125.6 ± 1.7) and DBP (77.0 ± 1.0) in 135 higher T excreters. Conclusion: Salt intake related BP rise with accelerated HR was affected by M and T intakes indicating dietary custom to take more M and T might attenuate salt induced BP rise.