MicroRNA expression and protein acetylation pattern in respiratory and limb muscles of Parp-1 −/− and Parp-2 −/− mice with lung cancer cachexia

Alba Chaconcabrera,Clara Fermoselle,Ida Salmela,Jose Yelamos,Esther Barreiro

Biochimica et Biophysica Acta (BBA) - General Subjects（2015）

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摘要

•Current treatment options for cachexia are limited•Muscle-enriched microRNAs and protein acetylation contribute to muscle wasting•Poly(ADP-ribose) polymerases (PARP) may play a role in muscle metabolism•MicroRNA and protein acetylation levels improved in diaphragm and gastrocnemius in Parp-1–/– and Parp-2–/– lung cancer cachectic mice•PARP-1 and -2 are involved in cancer-induced cachexia in respiratory and limb muscles

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关键词

Cancer-induced cachexia,Muscle-enriched microRNAs,Protein hyperacetylation,Myogenic transcription factors,Muscle structure and function,Parp-1−/− and Parp-2−/− mice

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