Multifunctional Thrombin-Activatable Polymer Capsules For Specific Targeting To Activated Platelets

Sylvia T. Gunawan,Kristian Kempe,Thomas Bonnard,Jiwei Cui,Karen Alt, Lok S. Law,Xiaowei Wang,Erik Westein,Georgina K. Such,Karlheinz Peter,Christoph E. Hagemeyer,Frank Caruso

ADVANCED MATERIALS（2015）

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摘要

Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.

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关键词

antibodies,drug delivery,plasminogen activators,polymer carriers,thrombosis

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