Phenotype and function of tissue-resident unconventional Foxp3-expressing CD4 + regulatory T cells

•Regulatory T cells (Tregs) are identified as a part of non-inflammatory process.•Tissue-resident Tregs have found in adipose, skin, muscle, intestine, central nervous system.•Tissue-specific Tregs have unique TCR repertoires, tissue specific factors, activation markers.•Tissue-resident Tregs possess distinguished function profiles in specific tissues.