HBD-3 induces NK cell activation, IFN-γ secretion and mDC dependent cytolytic function

Chelsey J. Judge,Elane Reyes-Aviles,Sara J. Conry,Scott S. Sieg,Zhimin Feng,Aaron Weinberg,Donald D. Anthony

Cellular Immunology（2015）

引用 15|浏览8

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摘要

•hBD-3 activates PBMC to secrete IFN-γ and kill target cells in mDC and NK dependent fashion.•TLR1, TLR2 and CCR2 are expressed on both mDC and NK cells and are involved in hBD-3 mediated activity.•hBD-3 activates NK cells, mDC, and likely facilitates mDC-NK interactions.

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关键词

Human,Defensin,Natural killer cell,Innate,Immunity,Dendritic cell

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