Increased hepatic Chemerin and CMKLR1 gene expression in human nonalcoholic fatty liver disease

Afh Pfeiffer,C Von Loeffelholz,Martin Stockmann,S Docke,J F Lock,S Hoppe,A Rieger,Martin O Weickert,Matthias Mohlig,Simone Florian,Martin A Osterhoff,Peter Neuhaus

Experimental and Clinical Endocrinology & Diabetes（2012）

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摘要

Objective: Inflammatory states of non-alcoholic fatty liver disease (NAFLD) are associated with obesity via adipocytokines. Circulating levels of the adipocytokine chemerin are in vivo associated with NAFLD and hepatic cirrhosis. However, hepatic gene transcription of chemerin and its receptor CMKLR1 are rarely studied, especially in human NAFLD.

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cmklr1 gene expression,hepatic chemerin,liver,gene expression

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